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MW 960.8 Da, Purity >95%. Potent inhibitor of L-glutamate uptake via the membrane bound excitatory amino acid transporter (EAAT). Able to antagonize AMPA and kainate receptor mediated currents (IC₅₀ values are 220 and 150 nM, respectively). Binds with high affinity to serum albumin.
MW 960.8 Da, Purity >95%. Potent inhibitor of L-glutamate uptake via the membrane bound excitatory amino acid transporter (EAAT). Able to antagonize AMPA and kainate receptor mediated currents (IC₅₀ values are 220 and 150 nM, respectively). Binds with high affinity to serum albumin.
A stable, cell-permeable molecule which generates free glutamic acid upon hydrolysis of the ester bond by cytoplasmic esterases; used in experiments to increase levels of cytoplasmic glutamic acid; also used to synthesize 5-octyl ester derivatives, including 5-octyl α-ketoglutarate, for delivery to cells
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